Transcranial Pulse Stimulation (TPS)

Diseases such as forgetfulness, attention deficit or Alzheimer's disease can profoundly affect quality of life. Traditional methods to combat these problems often offer limited benefits. Transcranial Pulse Stimulation (TPS) is a non-invasive, safe and innovative treatment option developed to support brain health and improve cognitive function.

Radiation-Free, Non-Surgical Next-Generation Treatment for Brain Health

As NPISTANBUL Hospital, we offer TPS treatment in accordance with scientific protocols and approved by international declarations (CE) and offer our patients both an effective and comfortable recovery process.

What is Transcranial Pulse Stimulation (TPS)?

Transcranial Pulse Stimulation (TPS) is a radiation-free and non-surgical treatment method that aims to improve cognitive functions by stimulating brain tissue without damaging it. This innovative technology uses focused low-intensity ultrasound pulses to reach deep areas of the brain and trigger biological activity in nerve cells.

TPS is a supportive and safe option, especially for individuals with Alzheimer's disease, memory disorders, attention deficit and cognitive decline.

As NPISTANBUL Hospital, we apply this treatment with personalized planning and advanced imaging systems in accordance with scientific protocols.

Personalized Treatment Approach

The brain structure and needs of each individual are different. For this reason, Transcranial Pulse Stimulation (TPS) treatment is not a standardized application, but a personalized planning.

Thanks to advanced imaging technologies, TPS systems precisely identify target areas and enable instantaneous monitoring of the treatment. This customized approach maximizes the effect of the treatment while increasing safety.

Steps of personalized TPS implementation:

• A 3D brain map is created using brain MRI data. This provides a detailed view of the patient's individual brain structure.
• Target areas to be treated are precisely identified with neuronavigation technology. Areas associated with memory, attention and cognitive functions are prioritized.
• The applied energy and treatment progress are monitored in real time. The system instantly monitors how much stimulation is given to which area during the session. Thus, every stage of the treatment is under control.

Thanks to all these data, a scientifically proven high-precision, effective and safe treatment process is provided.

In Which Diseases is Transcranial Pulse Stimulation (TPS) Used?

Transcranial Pulse Stimulation (TPS) is used as adjunctive therapy, particularly in the following neurological conditions

• Alzheimer's disease (especially early and mid-stage)
• Memory and learning disorders
• Attention deficit and concentration problems
• Mental slowdown and decreased cognitive performance
• Age-related cognitive decline
• Management of neurodegenerative disease processes

Before starting the treatment, our specialist physicians evaluate the patient's current condition and past medical data and make the appropriate decision.

What are the Benefits of Transcranial Pulse Stimulation?

Transcranial Pulse Stimulation (TPS) is one of the innovative treatment methods that have come to the fore in the field of brain health in recent years. It can be applied without disrupting the daily lives of patients with its non-surgical, radiation-free and customizable structure. It shows promising effects especially in cognitive problems such as Alzheimer's, memory disorders and attention deficit.

The prominent advantages of TPS treatment:

• It is non-surgical, non-invasive. No incision, needle or narcosis is required during the application.
• It does not involve radiation. The treatment is performed with ultrasonic waves; no ionizing radiation is used.
• It is applied in a short time. Each session takes an average of 30 minutes; total treatment is completed in a few weeks.
• It is painless and comfortable. The patient feels only a slight vibration; there is no discomfort during the application.

Scientifically Proven Benefits of TPS

Increases Neuroplasticity: The brain's capacity to reorganize and form new connections increases.

Improves Blood Circulation: Oxygen and nutrient flow in targeted areas increases; energy production of cells is supported.

Strengthens Neuronal Communication: Ultrasound pulses accelerate biochemical transitions in the cell membrane; cognitive functions are supported.

Reduces Inflammation: Helps reduce chronic inflammation in the brain.

Stimulates New Cell Production: Increased release of nerve cell growth factors, stimulates angiogenesis and neurogenesis.

How is Transcranial Pulse Stimulation (TPS) Therapy Applied?

Transcranial Pulse Stimulation (TPS) therapy is applied in a comfortable and patient-friendly manner. This method, which does not require surgical intervention, is performed in a clinical setting, without tiring the patient and without interrupting their daily life. The application is planned individually and is usually completed with a short-term treatment protocol.

Steps followed during TPS application:

• No surgery or anesthesia is required. TPS is a completely external, non-invasive procedure.
• The patient receives treatment in a seated position in a comfortable chair. Comfort is at the forefront throughout the procedure.
• A special conductive gel is applied to the head area. This gel ensures effective transmission of ultrasound pulses through the skin.
• Each session lasts approximately 30 minutes. These sessions, which are completed in a short time, do not tire the patient.
• Generally, a total of 6 sessions are applied in a 2-week period. If deemed necessary, "reminder sessions" can be added in the following periods.
• The patient can return to his/her daily life immediately after the procedure. There is no need for rest after the procedure.
• No haircut is required; the procedure is painless. Only a slight vibration sensation may be experienced, which is usually not uncomfortable.

Clinical and Preclinical Data Supporting the Effectiveness of TPS

• Significant improvements in tests such as MMSE, ADAS-Cog and CERAD have been reported in studies in patients with mild to moderate Alzheimer's disease.
• After treatment, an increase in memory network connections and improvement in daily living skills were observed.
• Neural connections were found to be strengthened in fMRI imaging.
• In animal models, TPS has been shown to positively affect hippocampal functions and spatial memory.

Are There Side Effects of TPS Treatment?

TPS has not shown any serious side effects in studies to date.

The most commonly reported side effects include

• Mild headache
• Short-term pain around the jaw
• Mild fatigue

All these effects are temporary and do not prevent patients from continuing treatment.

Why TPS Treatment?

Because Transcranial Pulse Stimulation:

• It is a scientifically supported solution against neurological diseases.
• It does not contain radiation and does not require surgical intervention.
• It increases the comfort of patients thanks to its painless and short-term application.
• It can be applied without interrupting daily life.
• It offers promising results in progressive diseases such as Alzheimer's.
• Provides maximum effect and safety with personalized planning.