What is Prolotherapy?

What is Prolotherapy?

Prolotherapy is an injection method used in the treatment of pain originating from ligaments, tendons, muscles, and joints. The aim of the treatment is to reduce pain by stimulating the body's natural healing mechanisms, to support tissue healing, and to provide functional recovery.

In Which Cases Can It Be Applied?

  • Lower back and neck pains
  • Knee, shoulder, hip, and ankle pains
  • Tendon and ligament injuries
  • Sports injuries
  • Tennis elbow and golfer's elbow
  • Plantar fasciitis and heel pains
  • Some chronic musculoskeletal pains

How Is the Procedure Performed?

The treatment solution is injected with the help of fine needles into the areas determined by examination. When necessary, the application can be performed under ultrasonography guidance. The procedure usually takes 10–30 minutes, and most patients can return to their daily activities on the same day.

Expected Benefits 

  • Reduction of pain
  • Increase in mobility
  • Support of joint and connective tissues
  • Relief in daily life activities

The effectiveness of the treatment may vary from person to person, and no absolute guarantee of success can be given for any medical procedure.

Possible Side Effects and Risks

Commonly Observed Conditions

  • Pain and tenderness at the injection site
  • Mild swelling
  • Bruising
  • Temporary limitation of movement

Rarely Observed Conditions

  • Bleeding
  • Infection
  • Temporary nerve irritation
  • Dizziness or feeling faint
  • Allergic reaction

Medication Use Before and After the Procedure

Since it is thought that nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the effectiveness of prolotherapy treatment, care should be taken regarding their use.

Before the Procedure

  • Unless your physician gives different advice, it is recommended to stop taking NSAID group medications 3 days before the procedure.
  • Inform your physician about all the medications you use regularly.
  • Be sure to inform your physician if you are using blood-thinning medications.
  • Do not stop your prescription medications without your physician's recommendation.

After the Procedure

  • It is recommended not to use NSAID group medications for at least 7 days, preferably 14 days after the procedure.
  • When pain control is needed, medication deemed appropriate by the specialist physician can be used.
  • Be sure to consult your physician when you need to use medication.

Things to Consider After the Procedure

  • Avoid heavy physical activities for the first 24 hours.
  • Mild pain and tenderness may be felt for the first few days.
  • Follow the exercise and rehabilitation program recommended by your physician.
  • Do not miss your control appointments.

In Which Cases Should You Apply to a Healthcare Institution?

  • Severe and progressively increasing pain
  • Fever above 38°C
  • Significant redness or swelling at the injection site
  • Development of discharge
  • Shortness of breath
  • Widespread rash or signs of allergic reaction
  • Development of loss of strength in the arm or leg
Created At:January 24, 2023|Updated At:July 28, 2026
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