MCHC (mean corpuscular hemoglobin concentration) is a blood test result in which the amount of hemoglobin in a person's blood is related to the volume of red blood cells (erythrocytes). MCHC is a parameter measured during blood analysis and shows the ratio of hemoglobin concentration to the volume of red blood cells. This measurement helps to determine how full or dense the red blood cells are.
What is a Normal MCHC Value?
The MCHC normal value can vary between laboratories and units of measurement, so exactly what ranges are considered normal depends on the laboratory's reference ranges. However, there is a generally accepted reference range, which is that MCHC is approximately between 32 and 36 deciliters per gram (g/dL).
What does high MCHC mean?
A high MCHC is not usually considered a sign of a serious health problem. However, if this value is above a certain level, specialists can further evaluate the condition by examining other blood values. One of the most common causes of this elevation is associated with a condition known as hemolytic anemia. In hemolytic anemia, red blood cells begin to break down earlier than normal, leading to increased hemoglobin levels and an elevated MCHC value. Hemolytic anemia can occur for a number of reasons, such as autoimmune anemia.
Another possible cause is a deficiency of vitamin B12 or folate. These deficiencies can cause red blood cells to grow differently from normal and produce more hemoglobin. In addition, a blood disorder called hereditary spherocytosis can also cause this value to rise.
If there is no underlying health problem causing a high MCHC value, some steps can be taken to promote health. A healthy diet can include more foods containing vitamin B12 and folate. Reducing alcohol and smoking can also help to improve this value. However, it is important to consult a specialist to interpret laboratory results such as a high MCHC value and determine treatment options.
What is the treatment for high MCHC?
A high MCHC value can be due to many different causes, so treatment for high MCHC is based on identifying the specific cause. Some common causes associated with elevated MCHC and treatment approaches for these causes can be listed as follows:
Hemolytic Anemia: Hemolytic anemia is a condition in which red blood cells break down before normal. Treatment is based on identifying the underlying cause. For example, immunosuppressive drugs may be used in autoimmune diseases such as autoimmune anemia.
Vitamin B12 or Folate Deficiency: Elevated MCHC may be due to vitamin B12 or folate deficiency. Treatment of these deficiencies is aimed at correcting the deficiencies. Oral or injectable supplements can be given for vitamin B12 deficiency.
Hereditary Spherocytosis: Inherited blood disorders, such as hereditary spherocytosis, may require specialized treatment. Treatment for these diseases is usually aimed at relieving symptoms and preventing complications.
Other Underlying Causes: Elevated MCHC may also be due to other causes (e.g. medication side effects, chronic diseases). It is important to identify and treat these causes.
Treatment may vary depending on each individual's specific condition and the underlying cause. Therefore, when an elevated MCHC is diagnosed, a comprehensive evaluation by a hematologist or specialist should be performed and an appropriate treatment plan determined. An untreated high MCHC value can lead to the progression of underlying health problems or complications, so it is important to follow the doctor's recommendations.
What Does Low MCHC Mean?
Low MCHC means that red blood cells contain less hemoglobin than normal. In addition, a low value may indicate the following conditions:
- Iron deficiency anemia,
- Vitamin B12 or folate deficiency,
- Thalassemia or other types of genetic anemia,
- Chronic diseases.
Can MCHC be lowered?
The MCHC value cannot be lowered because MCHC is measured as a laboratory test result and cannot be directly controlled. However, a low MCHC value can be an indicator of an underlying health problem or anemia. Therefore, treating the underlying problem that is causing the low MCHC value can bring MCHC values back to normal.
For example, if the MCHC value is low and the cause is iron deficiency anemia, treatments such as iron supplements or consuming iron-containing foods can increase iron levels and improve the MCHC value.
How is MCHC Calculated?
The MCHC value can be calculated automatically by blood count devices or manually if hemoglobin (Hgb) and hematocrit (Hct) values are known.
The formula used for this calculation is as follows: MCHC = Hgb/Hct x 100.
This formula calculates the ratio of the amount of hemoglobin in the blood to the percentage of hematocrit and obtains the MCHC value. This method is an important tool for better understanding and monitoring of laboratory test results.